MDR1: Multi Drug Resistance .
Slovenija (Eurovetgene) | France: MDR1(Dossier Collie-online) | ||||||||||||||||
The product of MDR1 gene is a protein responsible for transport of different substances across cell membrane. It is found in membranes of intestinal epithelial cells, proximal kidney tubules and liver hepatocytes. The action of this protein is connected to removal of certain molecules out of an organism through urine and bile. The protein is also found on a blood-brain boundary and is responsible for restriction of entry of such molecules into central nervous system. The protein is able to carry a wide spectrum of structurally unrelated drugs, toxins and xenobiotics as well as certain drugs commonly used in veterinary diagnostics. A mutation in MDR1 gene causes the production of non-functional protein which in turn causes sensitivity on certain drugs, especially ivermectin. |
MDR1 et la sensibilité médicamenteuse chez le Colley et 10 races proches. |
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MDR1 (Multi Drug Resistance) Chiens testés (Tested dogs) 8106